protein

EphB4 Protein, Human (HEK293, Fc)

HY-P74171

10 μg;50 μg;100 μg

60;155;250 USD

EphB4 Protein, Human (HEK293, Fc)

proteins

HEK293

10 μg;50 μg;100 μg

60;155;250 USD

EphB4 protein is a receptor tyrosine kinase that binds to ephrin B ligand and initiates bidirectional signaling. Positive signaling regulates the rejection and separation of cells from EFNB2-expressing cells. EphB4 Protein, Human (HEK293, Fc) is the recombinant human-derived EphB4 protein, expressed by HEK293 , with C-hFc labeled tag.

Human

EphB4 protein, a receptor tyrosine kinase, engages in promiscuous binding to transmembrane ephrin-B family ligands located on adjacent cells, initiating contact-dependent bidirectional signaling. The downstream pathway originating from the receptor is termed forward signaling, while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Collaborating with its cognate ligand, EFNB2, EphB4 is intricately involved in regulating cell adhesion and migration. Moreover, EphB4 assumes a central role in heart morphogenesis, angiogenesis, and the remodeling and permeability of blood vessels. The forward signaling mediated by EPHB4 is instrumental in controlling cellular repulsion and segregation from EFNB2-expressing cells.

Ephrin type-B receptor 4; EPHB4; HTK; MYK1; TYRO11

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice