protein

FLT3 Protein, Mouse (HEK293, His)

HY-P74151

5 μg;10 μg;50 μg

116;196;550 USD

FLT3 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

116;196;550 USD

FLT3, a receptor tyrosine kinase, has diverse functions including kinase activation, PI3K binding, and ligase binding. It plays a vital role in hematopoiesis, immune function, and tissue development. FLT3 is expressed in various tissues like the brain, immune system, and reproductive system. It is involved in diseases like leukemia and cancer. The wide functions and tissue-specific expression emphasize FLT3's importance in health and disease. FLT3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FLT3 protein, expressed by HEK293 , with C-His labeled tag.

Mouse

FLT3, a receptor tyrosine kinase, possesses diverse functional capabilities, including phosphatidylinositol 3-kinase binding, protein tyrosine kinase activity, and ubiquitin protein ligase binding. Its involvement in critical processes such as common myeloid progenitor cell proliferation, hemopoiesis, and lymphocyte proliferation highlights its essential role in hematopoietic development and immune system function. Situated on the external side of the plasma membrane, FLT3 exhibits biased expression in various tissues, including the brain, dorsal aorta, immune and reproductive systems, and spinal cord. This protein serves as a crucial player in diseases like acute myeloid leukemia and juvenile myelomonocytic leukemia, and its orthologs are implicated in conditions such as acute lymphoblastic leukemia, colorectal adenocarcinoma, hepatocellular carcinoma, and prostate cancer. The multifaceted functions and tissue-specific expression underscore the significance of FLT3 in cellular homeostasis and disease progression.

CD135; FL cytokine receptor; FLK2; Flk-2; Flt-3; STK-1

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.