protein

GSK-3 beta Protein, Human (sf9, His)

HY-P74114

5 μg;10 μg;20 μg;50 μg

87;150;248;545 USD

GSK-3 beta Protein, Human (sf9, His)

proteins

Sf9 insect cells

5 μg;10 μg;20 μg;50 μg

87;150;248;545 USD

GSK-3β is a serine-threonine kinase and negative regulator of glucose homeostasis. GSK-3β has been implicated in neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. GSK-3β is widely expressed in multiple tissues, with particularly high levels in the brain and thyroid gland. GSK-3 beta Protein, Human (sf9, His) is the recombinant human-derived GSK-3 beta protein, expressed by Sf9 insect cells , with N-His labeled tag.

Human

GSK-3 beta protein is a serine-threonine kinase in the glycogen synthase kinase subfamily that acts as a negative regulator of glucose homeostasis and plays a crucial role in energy metabolism, inflammation, endoplasmic reticulum stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene are associated with Parkinson's and Alzheimer's diseases and play an important role in neurodegenerative diseases. GSK-3 beta is widely expressed in the brain (RPKM 13.9), thyroid (RPKM 9.9), and 25 other tissues.

Glycogen synthase kinase-3 beta; GSK-3 beta; Gsk3b

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 25% glycerol, 0.5 mM PMSF, 0.5 mM EDTA.

Shipping with dry ice