protein

SIRP alpha/CD172a Protein, Human (HEK293, Fc)

HY-P7406

10 μg;50 μg

89;250 USD

SIRP alpha/CD172a Protein, Human (HEK293, Fc)

proteins

HEK293

10 μg;50 μg

89;250 USD

384647075

SIRP alpha/CD172a Protein, Human (P78324, HEK293, Fc) produced in HEK293 cells with the C-termimal human IgG1 Fc fragment. Signal regulatory protein alpha (SIRPα, designated CD172a) is a monomeric about 90kDa type I transmembrane glycoprotein that belongs to the SIRP/SHPS (CD172) family of the immunoglobulin superfamily.

Human

Signal regulatory protein α (SIRPα) is a glycoprotein receptor that recruits and signals via the tyrosine phosphatases SHP-1 and SHP-2.The cytoplasmic domain of SIRPα contains four immunoreceptor tyrosine-based inhibition motifs (ITIMs), which upon phosphorylation recruit and activate SH2-domain-containing phosphotyrosine phosphatases (PTPase) SHP-1 and SHP-2. In macrophages SIRPα can negatively regulate the phagocytosis of host cells and the production of tumor necrosis factor alpha. SIRPα ligation induces macrophage NO production through the cooperative action of JAK/STAT and PI3-K/Rac1/NOX/H2O2 signaling pathways. It proposes that SIRPα may function as an inhibitory receptor [1] .

rHuSignal regulatory protein α, Fc Chimera; CD172a; SHPS-1; BIT; MYD1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS or PBS, 5% trehalose and mannitol.

Room temperature in continental US; may vary elsewhere.