protein

PD-L2 Protein, Human (HEK293, Fc)

HY-P7399

10 μg;50 μg

90;190 USD

PD-L2 Protein, Human (HEK293, Fc)

proteins

HEK293

10 μg;50 μg

90;190 USD

384647068

PD-L2 Protein, Human (HEK293, Fc), a second ligand for PD-1, interacts with PD-1 negatively regulates T cell proliferation, cytokine production and cytotoxic activity.

Human

Programmed death I (PD-I)-deficient mice develop a variety of autoimmune-like diseases, which suggests that this immunoinhibitory receptor plays an important role in tolerance. PD-1 ligand 2 (PD-L2) is a second ligand for PD-1. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4+ T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals. In contrast, at high antigen concentrations, PD-L2-PD-1 interactions reduce cytokine production but do not inhibit T cell proliferation. PD-L-PD-1 interactions lead to cell cycle arrest in G0/G1 but do not increase cell death. In addition, ligation of PD-1 + TCR leads to rapid phosphorylation of SHP-2, as compared to TCR ligation alone [1] .

rHuPD-L2, Fc Chimera; Programmed cell death 1 ligand 2; B7DC; CD273

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against PBS, 5% trehalose and mannitol.

Room temperature in continental US; may vary elsewhere.