protein

I-309/CCL1 Protein, Human (HEK293, Fc)

HY-P73914

5 μg;10 μg;50 μg

77;130;365 USD

I-309/CCL1 Protein, Human (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg

77;130;365 USD

I-309/CCL1 Protein, Human (HEK293, Fc) is a cytokine that mediates inflammatory immune responses, viral infections, and tumorigenesis by interacting with the CCR8 chemokine receptor on the cell surface and attracting monocytes, natural killer cells, and immature B-cell nuclear dendritic cells. I-309/CCL1 Protein, Human (HEK293, Fc) is a recombinant human CCL1 (K24-K96) expressed by HEK293 with a -hFc tag at the nitrogen end [1] .

Human

CCL1 is a small glycoprotein belonging to the CC chemokine family with a molecular weight of approximately 15-16 kDa, known as small inducible cytokine I-309 in humans and TCA-3 in mice. CCL1 is secreted by activated monocytes, macrophages, T lymphocytes and endothelial cells and is chemotactic for monocytes but not for neutrophils [1] .    CCL1 can be activated by interaction with the cell surface chemokine receptor CCR8, which induces Ca 2+ influx, stimulates transient increases in cytoplasmic free calcium concentration in monocytes, and inhibits apoptosis in thymocyte lines via the RAS/MAPK pathway. Among others, CCR8 is constitutively expressed in monocytes, macrophages, Th2 and regulatory T lymphocytes and is the sole receptor for the human CCL1 and for the viral chemokine, vCCL1 (viral macrophage inflammatory protein 1). CCR8 has been shown to be associated with phagocytic macrophages and activated microglia in MS lesions and is directly related to demyelinating activity [2] .     CCL1 is involved in inflammatory processes through leukocyte recruitment and can play a key role in angiogenesis and other viral and neoplastic processes. A number of single nucleotide polymorphisms (SNPs) in the CCL1 gene have been associated with the progression of chronic obstructive pulmonary disease (COPD). In parallel, CCL1 plays a role in various CNS functions and diseases and may be associated with neuroinflammatory disorders [3] .

C-C motif chemokine 1; CCL1; SCYA1; TCA-3

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice.