protein

IL-33 Protein, Cynomolgus

HY-P73883

2 μg;10 μg;50 μg;100 μg

35;95;260;440 USD

IL-33 Protein, Cynomolgus

proteins

E. coli

2 μg;10 μg;50 μg;100 μg

35;95;260;440 USD

IL-33 Protein is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 acts intracellularly as a nuclear factor and extracellularly as a cytokine. IL-33 mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells. IL-33 Protein, Cynomolgus is the recombinant cynomolgus-derived IL-33 protein, expressed by E. coli , with tag free.

Cynomolgus

Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 superfamily and it main sources include human endothelial cells and mouse adventitial stromal cells of the vascular tree; epithelial cells in barrier tissues; fibroblast reticular cells (FRCs) in the lymphoid organs; and glial cells, neurons, and astrocytes in the nervous system. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 acts intracellularly as a nuclear factor and extracellularly as a cytokine. As a cytokine, IL-33 mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. Cellular stress or exposure to inflammation can augment or induce cellular expression of IL-33. IL-33 exhibits pleiotropic functions supporting IFN-γ-, IL-9-, and IL-17-dominated immune responses as part of the host response to pathogens or immune-mediated inflammatory diseases [1] [2] .

Interleukin-33; IL-33; IL-1F11; NF-HEV; DVS 27

Greater than 85% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.