protein

Integrin alpha 8 beta 1 Protein, Human (HEK293, Flag, His)

HY-P73869

5 μg;10 μg;50 μg;100 μg;500 μg

49;84;235;400;1120 USD

Integrin alpha 8 beta 1 Protein, Human (HEK293, Flag, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg

49;84;235;400;1120 USD

Integrin α-8/β-1 coordinates the recruitment of mesenchymal cells during renal organogenesis and recognizes RGD sequences in ligands such as TNC, FN1, SPP1, TGFB1, TGFB3, and VTN. It plays a role in multiple cellular interactions critical for organogenesis, including NPNT as a functional ligand in nephrogenesis. Integrin alpha 8 beta 1 Protein, Human (HEK293, Flag, His) is a recombinant protein dimer complex containing human-derived Integrin alpha 8 beta 1 protein, expressed by HEK293 , with C-10*His, C-Flag labeled tag. Integrin alpha 8 beta 1 Protein, Human (HEK293, Flag, His), has molecular weight of ~85-140 kDa.

Human

The Integrin alpha-8/beta-1 protein plays a crucial role in organogenesis, particularly in the development of the kidney and potentially other organs, by orchestrating the recruitment of mesenchymal cells into epithelial structures. Recognizing the R-G-D sequence within a broad spectrum of ligands, including TNC, FN1, SPP1, TGFB1, TGFB3, and VTN, Integrin alpha-8/beta-1 is implicated in diverse cellular interactions critical for organ formation. In kidney genesis, NPNT is identified as its likely functional ligand. Acting as a neuronal receptor for TNC, it regulates cell-cell interactions and modulates the neurite outgrowth of sensory and motor neurons. Structurally, Integrin alpha-8/beta-1 forms a heterodimer, with the alpha subunit comprising a heavy and a light chain linked by a disulfide bond. Specifically, the alpha-8 subunit associates with the beta-1 subunit, underscoring its integral role in mediating cell-matrix and cell-cell interactions during organ development and neural processes.

Integrin alpha 8 beta 1; ITGA8; ITGB1

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.