protein

Integrin alpha X beta 2 Protein, Human (HEK293, His)

HY-P73863

5 μg;10 μg;50 μg;100 μg

50;85;235;400 USD

Integrin alpha X beta 2 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

50;85;235;400 USD

Integrin α-X/β-2 is a receptor for fibrinogen that recognizes GPR sequences. It plays a key role in inflammatory responses, particularly in monocyte adhesion and chemotaxis. Integrin alpha X beta 2 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha X beta 2 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha X beta 2 Protein, Human (HEK293, His), has molecular weight of 130-150 kDa (ITGAX) & 85-96 kDa (ITGB2), respectively.

Human

The Integrin alpha-X/beta-2 protein serves as a receptor for fibrinogen, recognizing the G-P-R sequence in its ligands. Crucial for cell-cell interactions during inflammatory responses, Integrin alpha-X/beta-2 plays a particularly significant role in monocyte adhesion and chemotaxis. Structurally, it forms a heterodimer, consisting of an alpha and a beta subunit, with the alpha-X subunit associating with the beta-2 subunit. This receptor's recognition of fibrinogen and its involvement in inflammatory processes underscore its importance in facilitating immune responses, emphasizing its role in the regulation of monocyte functions and cell migration during inflammation.

Integrin alpha X beta 2; CD11c; ITGAX; CD18; ITGB2

Greater than 90% as determined by Tris-Bis PAGE or reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.