protein

M-CSF Protein, Rat

HY-P7386

10 μg;50 μg

190;590 USD

M-CSF Protein, Rat

proteins

E. coli

10 μg;50 μg

190;590 USD

384647055

M-CSF Protein, Rat is a pro-inflammatory cytokine, binds to its receptor CSF1R, and is involved in the development and proliferation of cells of the monocyte/macrophage lineage and participates in the induction of osteoclasts which are important in the destruction of bone and cartilage and in the periarticular osteoporotic changes.

Rat

Macrophage Colony Stimulating Factor (M-CSF) is a pro-inflammatory cytokine, constitutively produced by several cell types, such as fibroblasts, endothelial cells, stromal cells, macrophages, smooth muscle cells and osteoblasts, binds to its receptor CSF1R, and exists in several isoforms- as a secreted glycoprotein, a cell-surface protein and a proteoglycan [1] . M-CSF is involved in the development and proliferation of cells of the monocyte/macrophage lineage and participates in the induction of osteoclasts, which are important in the destruction of bone and cartilage and in the periarticular osteoporotic changes seen in patients with rheumatoid arthritis [2] .

rRtM-CSF; CSF-1; M-CSF

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against 50 mM Tris, 150 mM NaCl, pH 8.0.

Room temperature in continental US; may vary elsewhere.