protein

Serpin B5/Maspin Protein, Human (His)

HY-P7385A

10 μg;50 μg;100 μg

85;235;400 USD

Serpin B5/Maspin Protein, Human (His)

proteins

E. coli

10 μg;50 μg;100 μg

85;235;400 USD

Serpin B5/Maspin Protein is a tumor suppressor and a unique member of the serpin family. Maspin inhibits cancer cell invasion, attachment to the extracellular matrix, increases sensitivity to apoptosis, and inhibits angiogenesis. Maspin interacting with diverse group of intercellular and extracellular proteins, regulating cell adhesion, motility, apoptosis, and critically involved in mammary gland development. Maspin acts as an endogenous inhibitor of histone deacetylase (HDAC1). Serpin B5/Maspin Protein, Human (His) is the recombinant human-derived Serpin B5/Maspin protein, expressed by E. coli , with His labeled tag. The total length of Serpin B5/Maspin Protein, Human (His) is 375 a.a., with molecular weight of approximately 40-45 kDa.

Human

Maspin is a unique member of the serpin family that shares extensive homology with monocyte-neutrophil elastase inhibitor, PAI-2 and other serpins. Among the established anti-tumor effects of Maspin are the inhibition of cancer cell invasion, attachment to extracellular matrices, increased sensitivity to apoptosis, and inhibition of angiogenesis. Maspin interacting with diverse group of intercellular and extracellular proteins, regulating cell adhesion, motility, apoptosis, and angiogenesis and critically involved in mammary gland development. Maspin is an endogenous inhibitor of histone deacetylase (HDAC1) and reprograms tumor cells toward better differentiated phenotypes by inhibiting HDAC1.It stimulates an antitumor immune response in prostate tumor cells , leading to tumor elimination in vivo. Maspin may function as a modulator of the immune system in the tumor microenvironment [1] [2] .

rHuMaspin; Serpin B5; PI-5

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS

Room temperature in continental US; may vary elsewhere.