protein

Serpin B5/Maspin Protein, Human (375 a.a)

HY-P7385

5 μg;10 μg;50 μg;100 μg;500 μg

50;85;235;400;1120 USD

Serpin B5/Maspin Protein, Human (375 a.a)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg;500 μg

50;85;235;400;1120 USD

384647054

Serpin B5/Maspin Protein, Human (375 a.a) could inhibit invasion and motility of mammary tumors. Maspin Protein, Human is also found to be a potent angiogenesis inhibitor.

Human

Maspin is a unique member of the serpin family that shares extensive homology with monocyte-neutrophil elastase inhibitor, PAI-2 and other serpins. Maspin has been shown to inhibit invasion and motility of mammary tumors. Tumor transfectants expressing maspin exhibit decreased growth and metastasis in nude mice. Maspin gene expression is not detected in most breast tumors and loss of its expression is correlated with tumor invasiveness. Maspin is also found to be a potent angiogenesis inhibitor. In human breast tissue, maspin seems to be present more in luminal than myoepithelial cells, and it has been suggested that those maspin-expressing myoepithelial cells form a defensive barrier for the progression from ductal carcinoma in situ to more invasive carcinomas. A dispute exists regarding whether maspin acts as a protease inhibitor among biochemists [1] .

rHuMaspin; Serpin B5; PI-5

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS or 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.