protein

JAM-C/CD323 Protein, Mouse (HEK293, His)

HY-P73849

5 μg;10 μg;50 μg;100 μg

35;60;170;290 USD

JAM-C/CD323 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

35;60;170;290 USD

JAM-C/CD323 protein and JAM2 participate in a variety of cell-cell interactions and regulate cellular processes. It plays a key role in the homing and retention of hematopoietic cells in the bone marrow. JAM-C/CD323 Protein, Mouse (HEK293, His) is the recombinant mouse-derived JAM-C/CD323 protein, expressed by HEK293 , with C-His labeled tag.

Mouse

JAM-C/CD323 protein serves as a junctional adhesion molecule, engaging in heterotypic cell-cell interactions with its receptor JAM2 to modulate diverse cellular processes. It plays a pivotal role in the homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow, contributing to their retention on the surface of bone marrow stromal cells. Additionally, JAM-C is central to leukocyte extravasation, facilitating transmigration through the endothelium. In spermatogenesis, it forms interactions between Sertoli and germ cells, crucial for anchoring germ cells onto Sertoli cells and establishing cell polarity during spermatid differentiation. Acting as a counter-receptor for ITGAM, JAM-C mediates leukocyte-platelet interactions and regulates the transepithelial migration of polymorphonuclear neutrophils. Furthermore, it plays roles in angiogenesis, cell migration regulation, myocyte fusion during myogenesis, and promotes chemotaxis of vascular endothelial cells, thereby stimulating angiogenesis. The multifaceted functions of JAM-C underscore its significance in various cellular and physiological processes.

CD323; JAM-2; JAM3; JAMC; Junctional adhesion molecule C

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.