protein

Neprilysin/CD10 Protein, Rat (HEK293, His)

HY-P73746

5 μg;10 μg;50 μg;100 μg

60;100;280;480 USD

Neprilysin/CD10 Protein, Rat (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

60;100;280;480 USD

Neprilysin/CD10 protein has a specificity similar to thermolysin and mainly acts on polypeptides of up to 30 amino acids. It plays a crucial role in degrading opioid peptides, including Met-enkephalin and Leu-enkephalin, by cleaving the Gly-Phe bond. Neprilysin/CD10 Protein, Rat (HEK293, His) is the recombinant rat-derived Neprilysin/CD10 protein, expressed by HEK293 , with N-His labeled tag. The total length of Neprilysin/CD10 Protein, Rat (HEK293, His) is 699 a.a., with molecular weight of ~93 kDa.

Rat

The Neprilysin/CD10 Protein exhibits a thermolysin-like specificity but is primarily active on polypeptides of up to 30 amino acids. Biologically significant, it plays a crucial role in the degradation of opioid peptides, including Met- and Leu-enkephalins, achieved through the cleavage of a Gly-Phe bond. Additionally, Neprilysin/CD10 catalyzes the cleavage of bradykinin, substance P, and neurotensin peptides, and it can cleave angiotensin-1, angiotensin-2, and angiotensin 1-9. The protein is implicated in the degradation of the atrial natriuretic factor (ANF) and exhibits UV-inducible elastase activity towards skin preelastic and elastic fibers, highlighting its diverse enzymatic functions (By similarity).

Neprilysin; CALLA; NEP; SFE; CD10; MME

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.