protein

Profilin-4 Protein, Human (His)

HY-P73697

5 μg;10 μg;50 μg;100 μg

35;60;170;290 USD

Profilin-4 Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

35;60;170;290 USD

The profilin-4 protein is critical for male fertility and plays an important role in manchette development and acrosome biogenesis during spermatogenesis. It has binding affinity for a variety of phospholipids, including PtdIns(3)P, PtdIns(4,5)P2, PtdIns(4)P, and PA. Profilin-4 Protein, Human (His) is the recombinant human-derived Profilin-4 protein, expressed by E. coli , with N-His labeled tag. The total length of Profilin-4 Protein, Human (His) is 129 a.a., with molecular weight of ~14 kDa.

Human

Profilin-4 protein plays a crucial role in male fertility, being essential for manchette development and acrosome biogenesis during spermiogenesis. This protein exhibits binding affinity in vitro to various phospholipids, including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidic acid (PA). Notably, unlike other members of the profilin family, Profilin-4 does not bind to actin in vitro. These distinctive properties underscore its specialized functions in the intricate processes of male reproductive physiology, particularly in the development of manchette and acrosome during sperm maturation.

Profilin-4; Profilin IV; PFN4

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.