protein

IGFBP-4 Protein, Human (HEK293, C-His)

HY-P7369

2 μg;10 μg;50 μg

42;115;320 USD

IGFBP-4 Protein, Human (HEK293, C-His)

proteins

HEK293

2 μg;10 μg;50 μg

42;115;320 USD

385326035

IGFBP-4 Protein, Human is a member of the insulin-like growth factor-binding protein (IGFBP) family, binds to insulin-like growth factors, mediates IGF-independent biologic activities.

Human

The insulin-like growth factor-binding protein (IGFBP) family consists of six different protein members (IGFBP1-6) that show high inhibition for IGF-1 and IGF-2. IGFBP-4 is a smallest member and modulates the biologic functions by binding to IGFs. Moreover, IGFBP-4 mediates IGF-independent biologic activities. IGFBP-4 inhibits colorectal cancer, breast cancer and glioblastoma cells growth. IGFBP-4 acts a crucial inflammatory mediator in the occurrence of severities acute respiratory distress syndrome, which is responsible for cancer proliferation, migration and apoptosis [1] .

rHuIGF-BP-4, His; IBP-4; IGFBP-4; BP4

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS or 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.