product summary
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company name :
MedChem Express LLC
product type :
protein
product name :
SMAD3 Protein, Human/Mouse/Rat (sf9, His-GST)
catalog :
HY-P73636
quantity :
10 μg;50 μg;100 μg
price :
65;180;280 USD
more info or order :
product information
Catalog Number :
HY-P73636
Product Name :
SMAD3 Protein, Human/Mouse/Rat (sf9, His-GST)
Product Type :
proteins
Host Species :
Sf9 insect cells
Size :
10 μg;50 μg;100 μg
List Price :
65;180;280 USD
Product Description :
The SMAD3 protein is an R-SMAD that acts as an intracellular signal transducer activated by TGF-β and activin type 1 receptor kinase.It binds TRE elements and regulates TGF-β target genes.SMAD3 Protein, Human/Mouse/Rat (sf9, His-GST) is the recombinant rat-derived SMAD3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
SpeciesSummary :
Rat;Mouse;Human
Background :
The SMAD3 protein serves as a receptor-regulated SMAD (R-SMAD), functioning as an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. It binds the TRE element in the promoter region of genes regulated by TGF-beta, and upon forming the SMAD3/SMAD4 complex, activates transcription. Additionally, SMAD3 can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. This protein plays a role in wound healing, potentially modulating the growth and migration of primary keratinocytes and altering TGF-mediated chemotaxis of monocytes, with its impact on wound healing being hormone-sensitive. SMAD3 also acts as a regulator of chondrogenesis and osteogenesis and inhibits the early healing of bone fractures. Furthermore, it positively regulates PDPK1 kinase activity by stimulating its dissociation from the negative regulator 14-3-3 protein YWHAQ. The protein exists as a monomer in the absence of TGF-beta and forms a homooligomer in its presence, or a heterotrimer with C-terminally phosphorylated SMAD2 or SMAD3 and SMAD4 to form the transcriptionally active SMAD2/SMAD3-SMAD4 complex. SMAD3 interacts with various proteins involved in diverse cellular processes, including signal transduction, transcriptional regulation, ubiquitination, and protein-protein interactions.
ALTnames :
Mothers against decapentaplegic homolog 3; mMad3; Smad3; Madh3
Purity :
Greater than 85% as determined by reducing SDS-PAGE.
Buffer :
Supplied as a 0.2 μm filtered solution of 20mM Tris, 500mM NaCl, 10% Glycerol, pH 7.5, 2mM GSH.
Storage :
Shipping with dry ice
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA