protein

Latent TGF beta 1/TGFB1 Protein, Rat (HEK293, C-His)

HY-P73615A

2 μg;10 μg;50 μg;100 μg

55;150;420;720 USD

Latent TGF beta 1/TGFB1 Protein, Rat (HEK293, C-His)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg

55;150;420;720 USD

Latent TGF beta 1 (latent TGFB1) is the inactive form of TGF-B1. Latent TGF beta 1 associates with the extracellular matrix (ECM) via LTBP. LTBPs are components of the ECM, so that the proteolytic cleavage of LTBP can lead to the release of latent TGF-beta 1 from the matrix. Besides, the proteolytic cleavage and liberation of active TGFB1 is performed by BMP-1, by a variety of matrix metalloproteinases (MMPs) [1] [3] . Latent TGF beta 1/TGFB1 Protein, Rat (HEK293, C-His) is the recombinant rat-derived Latent TGF beta 1/TGFB1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Latent TGF beta 1/TGFB1 Protein, Rat (HEK293, C-His) is 361 a.a., with molecular weight of ~55 & 40 & 16 kDa, respectively.

Rat

TGF-B1 is known to be secreted in the inactive, latent form. And latent TGF beta 1 (latent TGFB1) is comprised of three distinct components: mature TGFB1 which is a disulphide-bonded dimer, the N-terminal remnant of theTGFB1 precursor and a novel type of protein denoted the latent TGFB1-binding protein (LTBP) [2] . Although latent TGF beta 1 is converted into its biologically active form by various mechanisms, but all mechanisms involve dissociation of TGFB1 from LAP-B1 in the soluble SLC (small latent complex) and/or the ECM bound LLC (large latent complex). In addition, Proteolytic cleavage is the most prominent cellular mechanism of latent TGFB1 activation. Latent TGF beta 1 associates with the extracellular matrix (ECM) via LTBP. LTBPs are components of the ECM, so that the proteolytic cleavage of LTBP can lead to the release of latent TGF-beta 1 from the matrix. Besides, the proteolytic cleavage of LLC and liberation of active TGFB1 is performed by BMP-1, by a variety of matrix metalloproteinases (MMPs) [1] [3] .

Transforming growth factor beta-1 proprotein; LAP; TGF-beta-1; TGFB1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.