protein

TIM-1/KIM-1/HAVCR Protein, Human (HEK293)

HY-P73605

50 μg;100 μg

400;680 USD

TIM-1/KIM-1/HAVCR Protein, Human (HEK293)

proteins

HEK293

50 μg;100 μg

400;680 USD

TIM-1/KIM-1/HAVCR Protein, Mouse (HEK293, His) belongs to a family of immunoglobulin-like domain-containing transmembrane proteins is widely accepted to be the receptor for hepatitis A virus (HAV), an unusual, hepatotropic human picornavirus. TIM1 (HAVCR1) facilitates attachment of a variety of enveloped viruses, including filoviruses, alphaviruses, and flaviviruses, that display highly conserved phosphatidylserine (PtdSer) on their surface. TIM1 undergoes tyrosine phosphorylation of its C-terminal cytoplasmic tail. TIM-1 can function as a co-stimulatory molecule for T cell activation [1] [2] [3] . TIM-1/KIM-1/HAVCR Protein, Human (HEK293) is the recombinant human-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with tag free. The total length of TIM-1/KIM-1/HAVCR Protein, Human (HEK293) is 270 a.a., with molecular weight of 90-110 kDa.

Human

TIM1 belongs to a family of immunoglobulin-like domain-containing transmembrane proteins that include three members in humans (human TIM1, TIM3, and TIM4) and eight members in mice (murine TIM1 to TIM8), of which the human TIM1, TIM3, and TIM4 are direct orthologs of murine TIM1, TIM3, and TIM4, respectively. These proteins are expressed on the cell surface, with their N-terminal immunoglobulin-like (IgV) and mucin domains present in the extracellular milieu and their C-terminal sequences in the cytoplasm. An important feature of all TIM proteins is a highly conserved phosphatidylserine (PtdSer)-binding pocket in the IgV domain that recognizes PtdSer on the outer membrane leaflet of apoptotic cells, facilitating their uptake by phagocytic cells [1] . TIM-1 is a type I membrane protein with an IgV domain followed by a heavily glycoslyated mucin domain, a transmembrane domain and an intracellular cytoplasmic tail with one tyrosine phosphorylation motif. TIM-1 can function as a co-stimulatory molecule for T cell activation. Cross-linking Tim-1 with antibodies, in conjunction with TCR and CD28 stimulation, enhances the proliferation of CD4+ T cells. over-expression of Tim-1 leads to NFAT/AP-1 transcriptional activation, dependent on Y276 in the cytoplasmic tail [2] .

Hepatitis A virus cellular receptor 1; HAVcr-1; KIM-1; TIM-1; CD365; HAVCR1

Greater than 80% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM NaCl, pH 8.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.