protein

TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His)

HY-P73602

5 μg;10 μg;50 μg;100 μg

35;60;165;280 USD

TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

35;60;165;280 USD

TIM-1/KIM-1/HAVCR protein is a phosphatidylserine receptor that plays a crucial regulatory role in regulatory B cells, affecting their generation, expansion and inhibitory functions. It acts as a ligand for P-selectin/SELPLG and controls activated T cell trafficking during inflammatory responses. TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His) is the recombinant rat-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with N-His labeled tag. The total length of TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His) is 221 a.a., with molecular weight of ~55-65 kDa.

Rat

TIM-1/KIM-1/HAVCR Protein serves as a phosphatidylserine receptor with a crucial functional role in the homeostasis of regulatory B-cells, influencing their generation, expansion, and suppressor functions. Additionally, as a ligand for P-selectin/SELPLG, it assumes a specialized role in the trafficking of activated T-cells during inflammatory responses, particularly controlling T-cell accumulation in the inflamed central nervous system and influencing the induction of autoimmune disease. TIM-1/KIM-1/HAVCR also regulates the expression of various anti-inflammatory cytokines and co-inhibitory ligands, including IL10, acting as a modulator of T-cell proliferation. Furthermore, it may play a role in kidney injury and repair. Interactions with STAM and SELPLG contribute to the multifaceted regulatory functions of TIM-1/KIM-1/HAVCR Protein.

Hepatitis A virus cellular receptor 1; HAVcr-1; KIM-1; TIM-1; CD365; HAVCR1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.