protein

Tissue Factor Protein, Rat (HEK293, His)

HY-P73592

10 μg;20 μg

159;270 USD

Tissue Factor Protein, Rat (HEK293, His)

proteins

HEK293

10 μg;20 μg

159;270 USD

Tissue Factor Protein plays a critical role in blood coagulation.It binds to coagulation factors, activating clotting cascades.Tissue Factor Protein interacts with cells, promoting thrombosis and inflammation.Understanding its functions can aid in developing treatments for blood disorders and cardiovascular diseases.Tissue Factor Protein, Rat (HEK293, His) is the recombinant rat-derived Tissue Factor protein, expressed by HEK293 , with C-His labeled tag.

Rat

Tissue Factor (TF) functions as a key initiator of blood coagulation, forming a complex with circulating factor VII or VIIa. This [TF:VIIa] complex is pivotal in activating factors IX or X through specific limited proteolysis. In normal hemostasis, TF plays a crucial role by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Additionally, TF interacts with HSPE; however, this interaction is inhibited by heparin. Notably, this interaction promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII, emphasizing the multifaceted role of TF in the intricate processes of blood clotting.

CD142; Coagulation Factor III; F3; TF; TFA; Tissue Factor

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.