protein

TRP1 Protein, Human (HEK293, His)

HY-P73568

5 μg;10 μg;50 μg;100 μg;500 μg

60;105;290;490;1370 USD

TRP1 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg

60;105;290;490;1370 USD

TRP1 (tyrosinase-related protein 1) is critical in melanin biosynthesis and catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) to indole-5,6-quinone-2- Carboxylic acids, especially in the presence of Cu(2+) ions. This activity is inhibited by Zn(2+). TRP1 Protein, Human (HEK293, His) is the recombinant human-derived TRP1 protein, expressed by HEK293 , with C-His labeled tag. The total length of TRP1 Protein, Human (HEK293, His) is 447 a.a., with molecular weight of ~60-75 kDa.

Human

TRP1 (Tyrosinase-related protein 1) plays a crucial role in melanin biosynthesis, as evidenced by its involvement in the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid, particularly in the presence of bound Cu(2+) ions. Notably, this enzymatic activity is inhibited in the presence of Zn(2+). TRP1 is implicated in regulating the type of melanin synthesized, thus influencing pigmentation processes. Additionally, to a lesser extent, TRP1 exhibits hydroxylating activity on tyrosine, contributing to melanin production. The multifaceted functions of TRP1 underscore its significance in melanogenesis and highlight its potential role in determining the characteristics of melanin generated in the skin.

5,6-dihydroxyindole-2-carboxylic acid oxidase; Catalase B; TRP-1; TYRP1; CAS2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.