protein

Tryptophan Hydroxylase 1/TPH-1 Protein, Human (His)

HY-P73566

5 μg;10 μg;50 μg

100;170;480 USD

Tryptophan Hydroxylase 1/TPH-1 Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg

100;170;480 USD

The tryptophan hydroxylase 1 (TPH-1) protein is key to serotonin biosynthesis, catalyzing the rate-limiting step: the oxidation of L-tryptophan to 5-hydroxy-L-tryptophan. This enzyme activity is critical for the synthesis of serotonin, a neurotransmitter that affects mood, sleep, and appetite. Tryptophan Hydroxylase 1/TPH-1 Protein, Human (His) is the recombinant human-derived Tryptophan Hydroxylase 1/TPH-1 protein, expressed by E. coli , with N-His labeled tag. The total length of Tryptophan Hydroxylase 1/TPH-1 Protein, Human (His) is 443 a.a., with molecular weight of ~48 kDa.

Human

Tryptophan Hydroxylase 1 (TPH-1) Protein plays a pivotal role in serotonin biosynthesis by catalyzing the rate-determining step, which involves the oxidation of L-tryptophan to 5-hydroxy-L-tryptophan. This enzymatic activity is crucial for the synthesis of serotonin, a neurotransmitter with essential roles in various physiological processes, including mood regulation, sleep, and appetite. TPH-1's ability to convert L-tryptophan to 5-hydroxy-L-tryptophan is a key regulatory step in the serotonin pathway, highlighting its significance in neurotransmitter production and neurotransmission.

TPH; TPH-1; TPRH; Tryptophan 5-hydroxylase 1; Tryptophan Hydroxylase 1

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 200 mM NaCl, 10% glycerol, pH 8.0.

Shipping with dry ice.