protein

VE-Cadherin Protein, Mouse (HEK293, His)

HY-P73559

5 μg;10 μg

90;150 USD

VE-Cadherin Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg

90;150 USD

VE-cadherin is a calcium-dependent glycoprotein critical for mediating cell adhesion and coordinating morphogenetic events during development. Lack of VE-cadherin in mice leads to uterine death due to increased endothelial cell apoptosis leading to vascular insufficiency. VE-Cadherin Protein, Mouse (HEK293, His) is the recombinant mouse-derived VE-Cadherin protein, expressed by HEK293 , with C-10*His labeled tag.

Mouse

VE-Cadherin, a member of the cadherin family, serves as a calcium-dependent glycoprotein crucial for mediating cell adhesion and orchestrating various morphogenetic events in development. The encoded preproprotein undergoes processing to generate a mature functional protein. In mice, the absence of VE-Cadherin leads to in utero mortality, primarily attributed to vascular insufficiency resulting from heightened endothelial apoptosis. Notably, multiple distinct genes within the cadherin family, including this gene, are situated on chromosome 8. The expression profile reveals bias towards certain tissues, with prominent levels observed in the lung and subcutaneous fat pad among others, underscoring its importance in tissue-specific functions.

Cadherin-5; VE-cadherin; CD144; CDH5

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.