protein

FGF-9 Protein, Mouse (N-His)

HY-P7352A

2 μg;10 μg;50 μg;100 μg

35;80;250;425 USD

FGF-9 Protein, Mouse (N-His)

proteins

E. coli

2 μg;10 μg;50 μg;100 μg

35;80;250;425 USD

FGF-9 is a member of mouse heparin-binding fibroblast growth factors located on the outside of cell membranes. FGF-9 is a regulator of chondrogenesis and vascularization during bone development. FGF-9 binds to fibroblast growth factor receptors ( FGFRs ) to activate downstream signaling pathways, such as PI3K-AKT, RAS-MAPK and protein kinase C (PKC) pathways. FGF-9 regulates embryonic development, cell proliferation, cell differentiation and cell migration. FGF-9 plays an important role in differentiation, survival of neuronal cells and growth stimulation of glial tumors. FGF-9 Protein, Mouse (N-His) is a recombinant protein with a N-His label that consisting of 208 amino acids and is produced in E. coli [1] [2] [3] [4] [5] .

Mouse

Fibroblast growth factors are important growth factors for physiological systems, and play critical and multifunctional roles during development, tumorigenesis, neuronal systems and disease progressions. FGF-9 Protein (Mouse) involves in neuronal disorders, plays an important role for brain development and functions [1] . FGF-9 Protein (Mouse) expression is principally restricted to the splanchnic mesodermal plate (SMP) and the mesothelium during early development, then subsequently expressed by both the mesothelium and rare epithelial cells splanchnic mesodermal plate (SMP) of mice [1] . Loss of FGF-9 Protein (Mouse) in mice leads to pancreatic hypoplasia and asplenia [1] . FGF-9 Protein (Mouse) reduces TBHP-induced oxidative stress in chondrocytes and diminishes mouse osteoarthritis by activating ERK/Nrf2 signaling pathway [2] . FGF-9 Protein (Mouse) inhibits cell apoptosis and senescence by activating intracellular HO-1 and γ-GCSc in PD models, upregulated Nrf2 expression and enhanced antioxidant effects in HD striatal cells [2] . FGF-9 Protein (Mouse) attenuates sepsis-induced fulminant hepatitis in mice [3] . FGF-9 Protein (Mouse) alleviates the infltration of neutrophils into the liver, and decreased the serum levels of pro‐infammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in Lipopolysaccharide (LPS) (HY-D1056)/D-galactosamine (D-Gal) (HY-42682) (LPS/D-Gal)-challenged mice [3] . FGF-9 Protein (Mouse) facilitates palatal growth and timely elevation by regulating cell proliferation and hyaluronic acid accumulation in mice [4] .

rMuFGF-9; FGF9; GAF; HBGF-9

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 8.5.

Room temperature in continental US; may vary elsewhere.