protein

VCAM-1/CD106 Protein, Human (HEK293, Fc)

HY-P73468

5 μg;10 μg;50 μg

45;75;200 USD

VCAM-1/CD106 Protein, Human (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg

45;75;200 USD

VCAM-1/CD106 proteins expressed on endothelial cells critically regulate leukocyte adhesion through integrin interactions, initiating calcium channel activation and RAC1-mediated transendothelial migration during inflammation. VCAM-1/CD106 Protein, Human (HEK293, Fc) is the recombinant human-derived VCAM-1/CD106 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VCAM-1/CD106 Protein, Human (HEK293, Fc) is 673 a.a., with molecular weight of 110-150 kDa.

Human

VCAM-1/CD106 is a cell adhesion glycoprotein predominantly expressed on endothelial cells, playing a pivotal role in immune surveillance and inflammation. As a major regulator of leukocyte adhesion to the endothelium, it interacts with various integrins, influencing immune cell interactions. During inflammatory responses, VCAM-1 binds ligands on activated endothelial cells, initiating calcium channel activation and RAC1 small GTPase activation, facilitating leukocyte transendothelial migration. Additionally, VCAM-1 acts as a quality-control checkpoint for entry into the bone marrow, providing a 'don't-eat-me' signal in the context of major histocompatibility complex (MHC) class-I presentation.

Vascular Cell Adhesion Protein 1; VCAM-1; INCAM-100; CD106; L1CAM

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.