protein

TrkB Protein, Canine (HEK293, His)

HY-P73461

5 μg;10 μg;50 μg;100 μg

42;70;200;340 USD

TrkB Protein, Canine (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

42;70;200;340 USD

TrkB Protein is a neurotrophic factor receptor and a member of the tropomyosin receptor kinase family. TrkB Protein has high affinity for brain-derived neurotrophic factor (BDNF) and plays a role in various physiological functions of neurons, including cell survival and differentiation. TrkB Protein has carcinogenic activity. TrkB Protein, Canine (HEK293, His) is the recombinant canine-derived TrkB protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkB Protein, Canine (HEK293, His) is 399 a.a., with molecular weight of ~60-78 kDa.

Canine

TrkB protein has a high affinity for brain-derived neurotrophic factor (BDNF) and plays a role in various physiological functions of neurons, including cell survival and differentiation [1] . TrkB protein is involved in epithelial-mesenchymal transition associated with increased migration and invasion in many cancer cell lines [3] . Abnormal activation caused by overexpression or fusion of TrkB protein can promote the genesis, progression, and treatment resistance of various types of neurogenic tumors [5] . Dysregulation of TrkB protein is associated with the pathogenesis of many diseases, such as neurodegenerative diseases, angiogenesis, lung adenocarcinoma, and gastric cancer [2] [3] [4] .

BDNF/NT-3 Growth Factors Receptor; Trk-B; NTRK2; TRKB

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, PH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.