protein

TIE-2 Protein, Rat (HEK293, Fc)

HY-P73438

2 μg;10 μg;50 μg;100 μg

30;55;115;175 USD

TIE-2 Protein, Rat (HEK293, Fc)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg

30;55;115;175 USD

TIE-2 protein has growth factor binding activity and is involved in ossification, cAMP response, and estrogen response. It is predicted to be present in a variety of cellular components, as a component of the plasma membrane, and as part of receptor complexes. TIE-2 Protein, Rat (HEK293, Fc) is the recombinant rat-derived TIE-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TIE-2 Protein, Rat (HEK293, Fc) is 721 a.a., with molecular weight of 120-130 kDa.

Rat

TIE-2 Protein possesses growth factor binding activity and is involved in various processes, including endochondral ossification, response to cAMP, and response to estrogen. It is predicted to be located in diverse cellular components such as basolateral plasma membrane, centriolar satellite, and microvillus, and is expected to be an integral component of the plasma membrane and part of a receptor complex. The predicted colocalization with actin filament and stress fiber suggests its potential involvement in cytoskeletal dynamics. Notably, TIE-2 serves as a biomarker for several diseases, including acute kidney tubular necrosis, brain ischemia, gastric ulcer, goiter, and hepatocellular carcinoma. The human ortholog(s) of this gene have been implicated in arteriovenous malformation and multiple cutaneous and mucosal venous malformations. The expression of TIE-2 is biased, with prominent levels observed in lung (RPKM 772.5), heart (RPKM 237.7), and various other tissues.

Angiopoietin-1 receptor; CD202b; hTIE2; p140 TEK; Tie2; VMCM

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.