protein

TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc)

HY-P73430

2 μg;10 μg;50 μg

46;130;360 USD

TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc)

proteins

HEK293

2 μg;10 μg;50 μg

46;130;360 USD

TGFBR2 is a transmembrane kinase that forms the TGF-β receptor complex with TGFBR1 and regulates various processes. Upon binding to cytokines, this complex activates TGFBR2, initiating SMAD-dependent signaling through phosphorylation of TGFBR1, SMAD2, and SMAD4. TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc) is the recombinant rat-derived TGFBR2/TGF-beta RII protein, expressed by HEK293 , with C-hFc labeled tag.

Rat

TGFBR2, a transmembrane serine/threonine kinase, partners with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, to form the specific receptor for TGF-beta cytokines, including TGFB1, TGFB2, and TGFB3. This receptor complex plays a pivotal role in transducing signals from the cell surface to the cytoplasm, thereby regulating diverse physiological and pathological processes. These include inducing cell cycle arrest in epithelial and hematopoietic cells, controlling mesenchymal cell proliferation and differentiation, influencing wound healing, extracellular matrix production, immunosuppression, and participating in carcinogenesis. The assembly of the receptor complex, comprising two TGFBR1 and two TGFBR2 molecules symmetrically bound to the cytokine dimer, leads to the constitutive activation of TGFBR2 and subsequent phosphorylation and activation of TGFBR1. Activated TGFBR1 then phosphorylates SMAD2, which dissociates from the receptor and forms a complex with SMAD4. This SMAD2-SMAD4 complex translocates to the nucleus, modulating the transcription of TGF-beta-regulated genes, thereby initiating the canonical SMAD-dependent TGF-beta signaling cascade. Additionally, TGFBR2 is involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II

Greater than 95% as determined by reducing SDS-PAGE

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice.