protein

Src Protein, Human (sf9, His-GST)

HY-P73422

50 μg;100 μg

260;440 USD

Src Protein, Human (sf9, His-GST)

proteins

Sf9 insect cells

50 μg;100 μg

260;440 USD

Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. Src Protein, Human (sf9, His-GST) is the recombinant human-derived Src protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Src Protein, Human (sf9, His-GST) is 536 a.a., with molecular weight of ~81 kDa.

Human

Src, a non-receptor protein tyrosine kinase, emerges as a central player in an array of cellular processes triggered by the engagement of diverse receptors, including immune response receptors, integrins, receptor protein tyrosine kinases, G protein-coupled receptors, and cytokine receptors. It orchestrates signaling pathways governing gene transcription, immune responses, cell adhesion, cell cycle progression, apoptosis, migration, and cellular transformation. While functional redundancy within the SRC kinase family complicates the identification of specific roles, SRC appears to be a primary kinase activated upon receptor engagement, influencing the activation of other protein tyrosine kinase (PTK) families. SRC is implicated in the regulation of cytoskeletal organization by phosphorylating substrates like AFAP1 and cortactin (CTTN). Its involvement extends to cell-cell and cell-matrix junctions, where it phosphorylates components such as beta-catenin (CTNNB1), delta-catenin (CTNND1), plakoglobin (JUP), and connexin-43 (GJA1). Additionally, SRC participates in PDGF-mediated tyrosine phosphorylation of STAT1 and STAT3, the RAS pathway, EGF-mediated calcium-activated chloride channel activation, and beta-arrestin desensitization. It also plays a crucial role in EGFR internalization, CDK20/MAPK3 mitogen-activated protein kinase cascade stimulation, and osteoclastic bone resorption. SRC's multifaceted activities highlight its intricate role in cellular regulation and signal transduction.

Proto-oncogene tyrosine-protein kinase Src; Src; p60-Src; SRC1

Greater than 90% as determined by reducing SDS-PAGE

Supplied as sterile 20 mM Tris, 500 mM NaCl, 20% Glycerol, pH 8.0, 0.5 mM TCEP.

Shipping with dry ice