protein

SMAC/Diablo Protein, Human (His)

HY-P73416

5 μg;10 μg;50 μg;100 μg

33;50;120;180 USD

SMAC/Diablo Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

33;50;120;180 USD

SMAC/Diablo protein is a core participant in apoptosis and activates caspases in the cytochrome c/Apaf-1/caspase-9 pathway. It antagonizes inhibitors of apoptosis proteins (IAPs), inhibits the binding of BIRC6/bruce to caspases and destabilizes XIAP/BIRC4. SMAC/Diablo Protein, Human (His) is the recombinant human-derived SMAC/Diablo protein, expressed by E. coli , with C-His labeled tag.

Human

SMAC/Diablo protein plays a pivotal role in apoptosis by instigating the activation of caspases within the cytochrome c/Apaf-1/caspase-9 pathway. Its mode of action involves counteracting the inhibitory effects of inhibitor of apoptosis proteins (IAP). SMAC/Diablo effectively hinders the activity of BIRC6/bruce by impeding its binding to caspases. Furthermore, it exerts its regulatory influence on XIAP/BIRC4 by diminishing its stability and apoptosis-inhibiting capabilities. This is achieved through the facilitation of XIAP/BIRC4 ubiquitination and subsequent degradation via the ubiquitin-proteasome pathway. Notably, SMAC/Diablo disrupts the interaction between XIAP/BIRC4 and processed caspase-9, thereby promoting the activation of caspase-3. In essence, SMAC/Diablo emerges as a key orchestrator in the intricate molecular machinery governing apoptotic processes.

SMAC; Diablo homolog, mitochondrial; DIABLO

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 50 mM Tris-HCL, 300 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.