protein

SLPI Protein, Human (107a.a, Sf9, His)

HY-P73414

5 μg;10 μg;50 μg;100 μg

82;140;385;683 USD

SLPI Protein, Human (107a.a, Sf9, His)

proteins

Sf9 insect cells

5 μg;10 μg;50 μg;100 μg

82;140;385;683 USD

The SLPI protein is an acid-stable protease inhibitor that has shown strong affinity for trypsin, chymotrypsin, elastase, and cathepsin G in multiple studies. It plays a critical regulatory role in inflammatory and immune responses following bacterial infection and Listeria monocytogenes infection. SLPI Protein, Human (107a.a, Sf9, His) is the recombinant human-derived SLPI protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of SLPI Protein, Human (107a.a, Sf9, His) is 107 a.a.

Human

SLPI, an acid-stable proteinase inhibitor, exhibits robust affinities for trypsin, chymotrypsin, elastase, and cathepsin G, as demonstrated in various studies. It plays a crucial role in modulating inflammatory and immune responses following bacterial infection, as well as infection by the intracellular parasite L.major. Additionally, SLPI contributes to down-regulating responses to bacterial lipopolysaccharide (LPS) (By similarity) and is involved in regulating the activation of NF-kappa-B, thereby influencing inflammatory responses. Notably, SLPI exhibits antimicrobial activity against mycobacteria but not against salmonella, contributing to normal resistance against infection by M.tuberculosis. It is also essential for normal resistance to infection by L.major and plays a critical role in wound healing, likely by preventing tissue damage through the regulation of protease activity (By similarity). Furthermore, in collaboration with ELANE, SLPI is required for the normal differentiation and proliferation of bone marrow myeloid cells, and it interacts with GRN, protecting progranulin from proteolysis.

Antileukoproteinase; ALP; BLPI; SLPI; MPI; WAP4; WFDC4

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 10% Glycerol.

Room temperature in continental US; may vary elsewhere.