protein

EGFR Protein, Human (621a.a, CHO, His)

HY-P7340

10 μg;50 μg

100;280 USD

EGFR Protein, Human (621a.a, CHO, His)

proteins

CHO

10 μg;50 μg

100;280 USD

384647038

EGFR Protein, Human (CHO, His) is a transmembrane protein with His tag. EGFR Protein exerts tyrosine kinase activity upon ligand induced activation.

Human

EGF Receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including TGFα, HB-EGF, Betacellulin (BTC), Amphiregulin, Epiregulin, and Epigen. Upon activation, EGFR initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers [1] .

rHuEGFR, His; ERBB; ERBB1; HER1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS or 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.