protein

ROR1 Protein, Human (sf9, His)

HY-P73390

5 μg;10 μg;50 μg;100 μg

67;114;320;544 USD

ROR1 Protein, Human (sf9, His)

proteins

Sf9 insect cells

5 μg;10 μg;50 μg;100 μg

67;114;320;544 USD

ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (sf9, His) is the recombinant human-derived ROR1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of ROR1 Protein, Human (sf9, His) is 331 a.a., with molecular weight of 55-70 kDa.

Human

ROR1 protein exhibits very low kinase activity in vitro, suggesting an unlikely role as a tyrosine kinase in vivo. It functions as a receptor for the ligand WNT5A, activating downstream NFkB signaling pathways and potentially inhibiting WNT3A-mediated signaling. Notably, in the inner ear, ROR1 is crucial for facilitating the innervation of auditory hair cells by spiral ganglion neurons.

Inactive tyrosine-protein kinase transmembrane receptor ROR1; ROR1; NTRKR1

Greater than 95% as determined by reducing SDS-PAGE

Supplied as sterile 20 mM Tris, 500 mM NaCl, 2 mM GSH, 3 mM DTT, 10% glycerol, pH 7.4

Shipping with dry ice