protein

P-Selectin Protein, Mouse (HEK293, Fc)

HY-P73383

5 μg;10 μg;50 μg;100 μg

57;90;235;380 USD

P-Selectin Protein, Mouse (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

57;90;235;380 USD

P-selectin is a Ca(2+)-dependent receptor on myeloid cells that specifically binds to carbohydrates on neutrophils and monocytes.It mediates interactions between activated endothelial cells or platelets and leukocytes by recognizing sialic acid-Lewis X.P-Selectin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived P-Selectin protein, expressed by HEK293 , with C-hFc labeled tag.

Mouse

The P-selectin protein is a Ca(2+)-dependent receptor found on myeloid cells, which specifically binds to carbohydrates on neutrophils and monocytes. It plays a crucial role in mediating the interaction between activated endothelial cells or platelets and leukocytes. The ligand recognized by P-selectin is sialyl-Lewis X. P-selectin facilitates the rapid rolling of leukocytes over vascular surfaces during the initial stages of inflammation by interacting with SELPLG. It also interacts with SNX17. Moreover, P-selectin interacts with SELPLG/PSGL1 and PODXL2, promoting neutrophil adhesion and leukocyte rolling. This interaction requires the presence of the sialyl-Lewis X epitope on SELPLG and PODXL2, as well as specific tyrosine sulfation on SELPLG.

P-selectin; GMP-140; LECAM3; PADGEM; CD62P; Selp

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4

Room temperature in continental US; may vary elsewhere.