protein

Serpin F1 Protein, Mouse (HEK293, His)

HY-P73372

50 μg

345 USD

Serpin F1 Protein, Mouse (HEK293, His)

proteins

HEK293

50 μg

345 USD

Serpin F1 is a neurotrophin that significantly induces extensive neuronal differentiation of retinoblastoma cells and exhibits potent anti-angiogenic effects.Its unique conformation lacks the S (stress) to R (relaxation) transition typical of active serpins, resulting in a lack of serpin activity.Serpin F1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin F1 protein, expressed by HEK293 , with C-His labeled tag.

Mouse

Serpin F1, a neurotrophic protein, emerges as a key inducer of extensive neuronal differentiation in retinoblastoma cells. Notably, it exerts a potent inhibitory effect on angiogenesis. Distinguished by its unique conformational characteristics, Serpin F1 does not undergo the S (stressed) to R (relaxed) transition typical of active serpins, resulting in the absence of serine protease inhibitory activity. Furthermore, its interaction with PNPLA2 serves to stimulate the phospholipase A2 activity of PNPLA2, underscoring the multifaceted roles of Serpin F1 in cellular processes.

Pigment epithelium-derived factor; Pedf; Sdf3; Caspin; Serpin F1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.