protein

CD28 Protein, Human/Cynomolgus/Rhesus Macaque (HEK293, hFc)

HY-P7334

5 μg;10 μg;50 μg

50;85;225 USD

CD28 Protein, Human/Cynomolgus/Rhesus Macaque (HEK293, hFc)

proteins

HEK293

5 μg;10 μg;50 μg

50;85;225 USD

384647032

CD28 Protein, Human/Cynomolgus/Rhesus Macaque (HEK293, hFc) is a polypeptide chain with the C-terminal human IgG1 Fc fragment produced in HEK293 cells. CD28, a T cell costimulatory receptor, is a primary target for PD-1-mediated inhibition.

Human

CD28 is the quintessential costimulatory molecule expressed on CD4 + and CD8 + T cells. During chronic infections and the normal aging process, CD28 expression is lost, compromising the functional activity of T cells. CD28 loss is promoted by replicative stress, particularly in the presence of tumor necrosis factor–α, owing to an inoperative CD28 initiator element. The co-receptor CD28 is strongly preferred over the T cell receptor (TCR) as a target for dephosphorylation by PD-1-recruited Shp2 phosphatase [1] .

rHuCD28, Fc Chimera; TP44

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against PBS or 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.

Room temperature in continental US; may vary elsewhere.