protein

BMP-3B/GDF10 Protein, Human (His)

HY-P7332

2 μg;10 μg;50 μg

45;126;353 USD

BMP-3B/GDF10 Protein, Human (His)

proteins

E. coli

2 μg;10 μg;50 μg

45;126;353 USD

384647030

Bone morphogenetic protein 3 (BMP-3; GDF10) is a polymorphic ligand protein belonging to the TGF-β family. BMP-3 is the main component of osteoblast and has osteogenic activity [1] . BMP-3 plays an inhibitory role in the carcinogenic process, and inhibits the occurrence of colon tumors through ActRIIB/ SMad2-dependent and TAK1/JNK signaling pathways [2] . BMP-3B/GDF10 Protein, Human has a total length of 110 amino acids (Q369-R478), is expressed in E. coli cells.

Human

Bone Morphogenetic Protein 3 (BMP-3) is a ligand protein with pleiotropic, belongs to TGFβ family. BMP-3 is a major component of osteogenin, which has osteogenic activity [1] . BMP-3 is widely found in different animals, while the sequence in human is lowly similar to Rat (81.94%), and mouse (80.86%). BMP-3 particularly serves as a reliable biomarker for screening colorectal cancer (CRC) because BMP-3 is hypermethylated and its protein expression is significantly reduced in cancer cell lines [2] . BMP-3 also plays a suppressor role in carcinogenesis, suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways [2] . BMP-3 could exert two-way regulatory effects on activin signaling in distinct cell types. BMP-3 stimulates proliferation of human mesenchymal stem cells which could be blocked by TGF-β/activin receptor kinase inhibitors [3] . BMP/TGFβ signaling to involve in vascular and valvular homeostasis, which is a critical process of embryonic development [4] . And BMP/TGFβ signaling can be terminated by inhibitory SMADs including SMAD6 and SMAD7, which are activated and induced by BMP signaling and switch off BMP signaling via multiple mechanisms [5] .

rHuBMP-3B; BIP; BMP-3B; GDF-10

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, 6% Trehalose, pH 7.4.

Room temperature in continental US; may vary elsewhere.