protein

N-Cadherin Protein, Human (HEK293, His)

HY-P73302

5 μg;10 μg;50 μg;100 μg

102;173;485;825 USD

N-Cadherin Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

102;173;485;825 USD

N-Cadherin Protein forms dimers with CDH2 chains, promoting cell-cell adhesion and sorting of cell types. It regulates neural stem cell quiescence by anchoring them to ependymocytes, disrupted by MMP24 cleavage. It also promotes cell-to-cell junctions and neurite branching, and regulates dendritic spine density. N-Cadherin Protein interacts with CDCP1, PCDH8, OBSCN, FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43, CTTN, and FBXO45. N-Cadherin Protein, Human (699a.a, HEK293, His) N-Cadherin Protein, Human (HEK293, His) is the recombinant human-derived N-Cadherin protein, expressed by HEK293 , with C-His labeled tag.

Human

N-Cadherin Protein is a calcium-dependent cell adhesion protein that plays a crucial role in homotypic cell-cell adhesion by forming dimers with CDH2 chains from neighboring cells. This interaction between cadherins contributes to the sorting of different cell types. In the adult subependymal zone, N-Cadherin Protein regulates the quiescence of neural stem cells by anchoring them to ependymocytes. However, when cleaved by MMP24, this anchorage is disrupted, leading to the modulation of neural stem cell quiescence. N-Cadherin Protein also plays a role in the formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells, promoting the extension of processes by the latter. Furthermore, it is essential for proper neurite branching and pre- and postsynaptic organization. N-Cadherin Protein may be involved in neuronal recognition mechanisms and the regulation of dendritic spine density in hippocampal neurons. It can form homodimers or heterodimers with other cadherins, and these interactions occur in trans, meaning with cadherin chains from neighboring cells. N-Cadherin Protein interacts with various proteins, including CDCP1, PCDH8, and OBSCN, and it has been found in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43, and CTTN. Additionally, it has been shown to interact with FBXO45.

Cadherin-2; CD325; CDH2; CDHN; CDw325; NCAD; N-cadherin 1

Greater than 90% as determined by reducing SDS-PAGE or Tris-Bis PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.