protein

MICB Protein, Human (HEK293, His)

HY-P73294

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

40;68;190;320;1100;2000 USD

MICB Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

40;68;190;320;1100;2000 USD

MICB Protein, a heavily glycosylated ligand for NKG2D receptor, triggers cytolytic response in immune cells. It resembles MHC class I molecules but lacks association with beta-2-microglobulin or peptide binding. Alternative splicing leads to multiple transcript variants. MICB is widely expressed, especially in lymph nodes and bone marrow, highlighting its immune response role in diverse physiological contexts. MICB Protein, Human (HEK293, His) is the recombinant human-derived MICB protein, expressed by HEK293 , with C-His, C-6*His labeled tag. The total length of MICB Protein, Human (HEK293, His) is 276 a.a., with molecular weight of ~45 kDa.

Human

MICB encodes a heavily glycosylated protein that serves as a ligand for the NKG2D type II receptor. Upon binding, this ligand triggers the cytolytic response of various immune cells, including natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells expressing the receptor. Notably, MICB is stress-induced and shares similarities with MHC class I molecules, although it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing generates multiple transcript variants, adding to the complexity of its functional repertoire. The expression of MICB is broad, with notable presence in lymph nodes, bone marrow, and various other tissues, underscoring its role in immune responses across diverse physiological contexts.

MHC class I polypeptide-related sequence B; MIC-B; PERB11.2

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.