protein

Lyn Protein, Human (sf9, GST)

HY-P73283

50 μg

488 USD

Lyn Protein, Human (sf9, GST)

proteins

Sf9 insect cells

50 μg

488 USD

Lyn protein is a non-receptor tyrosine protein kinase that centrally mediates signals from diverse cell surface receptors, regulating immune responses, hematopoiesis, and integrin signaling. It acts as a negative or positive regulator depending on the context, affecting B cell responses, differentiation and inflammatory responses. Lyn Protein, Human (sf9, GST) is the recombinant human-derived Lyn protein, expressed by Sf9 insect cells , with N-GST labeled tag.

Human

Lyn Protein, a non-receptor tyrosine-protein kinase, serves as a central mediator in transmitting signals from cell surface receptors, playing a crucial role in regulating innate and adaptive immune responses, hematopoiesis, growth factor and cytokine responses, integrin signaling, and the cellular response to DNA damage and genotoxic agents. Acting primarily as a negative regulator but also functioning as an activator depending on the cellular context, Lyn Protein is indispensable for initiating and terminating B-cell responses, influencing B-cell differentiation, proliferation, survival, apoptosis, and immune self-tolerance. It acts downstream of various immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2, and TLR4, contributing to the inflammatory response to bacterial lipopolysaccharide. Lyn Protein also mediates responses to cytokines and growth factors in diverse hematopoietic cell types, playing a crucial role in integrin signaling. Its regulatory role encompasses cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Lyn Protein down-regulates signaling pathways through phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), facilitating the recruitment of phosphatases such as PTPN6/SHP-1, PTPN11/SHP-2, and INPP5D/SHIP-1 to modulate signaling by dephosphorylation of kinases and substrates. Lyn Protein's multifaceted kinase activity extends to phosphorylating various substrates, including BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK, and TEC, showcasing its intricate involvement in diverse signaling cascades. It is also involved in the phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2, INPP5D/SHIP-1, BCR-ABL fusion protein, FER, KIT, LPXN, SCIMP, CLNK, BCAR1/CAS, and NEDD9/HEF1, illustrating its extensive regulatory capacity in various cellular processes.

Hck-2; JTK8; Tyrosine-protein kinase Lyn

Greater than 90% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of 50 mM Tris, 100 mM NaCl, pH 8.0, 0.5 mM Reduced Glutathione, 10% gly, 0.5 mM PMSF

Shipping with dry ice.