protein

LOK Protein, Human (His)

HY-P73282

50 μg

420 USD

LOK Protein, Human (His)

proteins

E. coli

50 μg

420 USD

LOK is an important serine/threonine protein kinase that significantly regulates lymphocyte migration by phosphorylating MSN and potentially PLK1. It acts as a negative regulator of MAP3K1/MEKK1. LOK Protein, Human (His) is the recombinant human-derived LOK protein, expressed by E. coli , with N-His labeled tag. The total length of LOK Protein, Human (His) is 300 a.a., with molecular weight of ~40 kDa.

Human

LOK, a serine/threonine-protein kinase, plays a significant role in the regulation of lymphocyte migration. It achieves this by phosphorylating key targets such as MSN and potentially PLK1, while also acting as a negative regulator of MAP3K1/MEKK1. LOK's involvement in the orchestration of lymphocyte migration is particularly notable, as it mediates the phosphorylation of ERM proteins, exemplified by MSN. Moreover, LOK may extend its influence as a cell cycle regulator, potentially functioning as a polo kinase kinase, as suggested by its ability to phosphorylate PLK1 in vitro; however, the confirmation of such regulatory roles in vivo awaits additional empirical evidence.

Serine/threonine-protein kinase 10; STK10; LOK

Greater than 95% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 8.0

Shipping with dry ice.