protein

Leptin R/LEPR Protein, Human (HEK293, His-Fc)

HY-P73273

5 μg;10 μg;50 μg

46;79;220 USD

Leptin R/LEPR Protein, Human (HEK293, His-Fc)

proteins

HEK293

5 μg;10 μg;50 μg

46;79;220 USD

PSAP/prosaposin protein is a multifunctional protein involved in various cellular processes. It serves as a precursor to four different saponin proteins involved in lipid metabolism and lysosomal function. Leptin R/LEPR Protein, Human (HEK293, His-Fc) is the recombinant human-derived Leptin R/LEPR protein, expressed by HEK293 , with C-hFc, C-8*His labeled tag.

Human

The Leptin R/LEPR Protein, a member of the gp130 family of cytokine receptors, activates gene transcription through the cytosolic STAT proteins. Serving as a receptor for leptin—an adipocyte-specific hormone crucial for body weight regulation—this protein plays a pivotal role in the regulation of fat metabolism and contributes to a novel hematopoietic pathway essential for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction, underscoring its significance in metabolic and endocrine functions. Notably, alternative splicing produces transcript variants encoding different isoforms, and it is noteworthy that this gene shares the same promoter and the first two exons with the LEPROT gene, albeit encoding distinct proteins. The gene displays ubiquitous expression, with elevated levels observed in the liver (RPKM 22.2), endometrium (RPKM 12.0), and 23 other tissues, indicating its diverse roles across various physiological contexts in multiple organs.

Leptin receptor; LEP-R; HuB219; OB-R; CD295; DB

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.