protein

Kininogen-1 Protein, Human (626a.a, HEK293, His)

HY-P73266

10 μg;50 μg

175;515 USD

Kininogen-1 Protein, Human (626a.a, HEK293, His)

proteins

HEK293

10 μg;50 μg

175;515 USD

Kininogen-1 protein undergoes alternative splicing, producing high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for coagulation, assembly of the kallikrein-kinin system, and release of the antimicrobial bradykinin. Kininogen-1 Protein, Human (626a.a, HEK293, His) is the recombinant human-derived Kininogen-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Kininogen-1 Protein, Human (626a.a, HEK293, His) is 626 a.a., with molecular weight of 100-110 kDa.

Human

Kininogen-1 Protein undergoes alternative splicing to yield two distinct proteins—high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK plays a crucial role in blood coagulation and the assembly of the kallikrein-kinin system. Additionally, HMWK releases bradykinin, a peptide with various physiological effects and antimicrobial properties against bacteria and fungi. In contrast, LMWK is not implicated in blood coagulation. Notably, during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, a reduction or depletion of angiotensin converting enzyme 2 (ACE2) leads to an elevation in des-Arg(9)-bradykinin levels, a bioactive bradykinin metabolite associated with lung injury and inflammation. The gene exhibits restricted expression primarily in the liver (RPKM 432.8).

Kininogen-1; HMWK; KNG1; BDK; KNG

Greater than 85% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 25 mM Tris, 100 mM NaCl, pH 7.5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.