protein

Kallikrein-8 Protein, Human (HEK293, His)

HY-P73265

50 μg

620 USD

Kallikrein-8 Protein, Human (HEK293, His)

proteins

HEK293

50 μg

620 USD

Kallikrein-8 protein is a serine protease that degrades proteins such as casein, fibrinogen, kininogen, fibronectin, and type IV collagen. It cleaves L1CAM in response to neural activity, promoting neurite growth in hippocampal neurons. Kallikrein-8 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-8 protein, expressed by HEK293 , with C-His labeled tag.

Human

Kallikrein-8 Protein is a serine protease known for its ability to degrade various proteins including casein, fibrinogen, kininogen, fibronectin, and collagen type IV. It also cleaves L1CAM in response to heightened neural activity, leading to neurite outgrowth and fasciculation in cultured hippocampal neurons. This protein plays a crucial role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, thereby regulating Schaffer-collateral long-term potentiation in the hippocampus and contributing to memory acquisition and synaptic plasticity. Additionally, Kallikrein-8 is involved in skin desquamation, keratinocyte proliferation, and plays a role in the secondary phase of pathogenesis following spinal cord injury.

Kallikrein-8; hK8; Neuropsin; Ovasin; TADG-14; NRPN; PRSS19

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.