product summary
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company name :
MedChem Express LLC
product type :
protein
product name :
IRAK4 Protein, Human (sf9, His)
catalog :
HY-P73255
quantity :
50 μg
price :
550 USD
more info or order :
product information
Catalog Number :
HY-P73255
Product Name :
IRAK4 Protein, Human (sf9, His)
Product Type :
proteins
Host Species :
Sf9 insect cells
Size :
50 μg
List Price :
550 USD
Product Description :
The IRAK4 protein is a serine/threonine protein kinase that is critical for initiating the innate immune response through the Toll-like receptor (TLR) and IL-1R signaling pathways. After TLR is activated, it rapidly forms the Myddosome with IRAK2. IRAK4 Protein, Human (sf9, His) is the recombinant human-derived IRAK4 protein, expressed by Sf9 insect cells , with N-10*His labeled tag. The total length of IRAK4 Protein, Human (sf9, His) is 460 a.a., with molecular weight of ~48 kDa.
SpeciesSummary :
Human
Background :
The IRAK4 protein functions as a pivotal serine/threonine-protein kinase, playing a crucial role in initiating the innate immune response against foreign pathogens. It is actively involved in Toll-like receptor (TLR) and IL-1R signaling pathways, and upon TLR activation, it is rapidly recruited by MYD88 to form the Myddosome in conjunction with IRAK2. Initially, IRAK1 is phosphorylated, stimulating its kinase activity and inducing intensive autophosphorylation. Additionally, IRAK4 phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2, and PELI3), facilitating pellino-mediated polyubiquitination of IRAK1. Consequently, the polyubiquitinated IRAK1 binds with the ubiquitin-binding domain of IKBKG/NEMO, assembling the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. This, in turn, activates IKKs (CHUK/IKKA and IKBKB/IKKB), leading to nuclear translocation and activation of NF-kappa-B. Alternatively, TIRAP is phosphorylated by IRAK4, promoting its ubiquitination and subsequent degradation. Moreover, IRAK4 phosphorylates NCF1, which regulates NADPH oxidase activation following LPS stimulation, suggesting a similar mechanism during microbial infections.
ALTnames :
Interleukin-1 receptor-associated kinase 4; IPD1; IRAK4; NY-REN-64; REN64
Purity :
Greater than 90% as determined by reducing SDS-PAGE
Buffer :
Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, 0.5 mM PMSF, pH 7.4
Storage :
Shipping with dry ice.
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA