protein

IFN-alpha 2/IFNA2 Protein, Mouse (HEK293, Fc)

HY-P73248

5 μg;10 μg;20 μg;50 μg

79;135;225;375 USD

IFN-alpha 2/IFNA2 Protein, Mouse (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;20 μg;50 μg

79;135;225;375 USD

IFN-alpha 2 (IFNA2), belongs to type I interferon family, is a protein secreted by cells infected by a virus and acting on other cells to inhibit viral infection [1] . IFN-alpha 2 exerts cytotoxic activity against CD8 + T cells and induces CD4 + T cell depletion [3] . IFN-alpha 2/IFNA2 Protein, Mouse (HEK293, Fc) contains 167 a.a. (C24-E190), is produced in HEK293 cells with a N-terminal hFc-tag.

Mouse

IFN-alpha 2 (IFNA2; IFN-α2), belongs to the type I interferon family, produced by the plasmacytoid dendritic cells (pDCs) exposure to HIV-1BaL in order to inhibit viral infection [1] . Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively [2] . IFN-alpha 2 subtype is the only one that is currently licensed to treat infections caused by hepatitis B virus (HBV) and HCV [3] . IFN-alpha 2 shows a Sortilin-dependent trafficking in cells and increases the expression level of interferon-stimulated genes (ISGs) in HIV-infected cells [1] [4] . It also exhibits cytotoxic activity against CD8 + T cells and enhances CD4 + T cell depletion [3] . Among the IFN-alpha 2 alleles, IFN-alpha 2b is being the predominant allele while IFNα-2a is less predominant and IFNα-2c only a minor allelic variant [5] . IFN-alpha 2 has a bored application in research of cancer, including some hematological malignancies and solid tumors [6] . As for a wildly use of IFN in animal disease model, the sequence of amino acids in IFNA2a protein of mouse is very different from human (59.57%).

Interferon alpha-2; IFN-alpha-2; LeIF A; IFNA2; IFNA2A

Greater than 90% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4

Shipping with dry ice.