protein

INHBB Protein, Human (HEK293, His)

HY-P73242

5 μg;10 μg;20 μg;50 μg;100 μg

128;205;345;533;850 USD

INHBB Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;20 μg;50 μg;100 μg

128;205;345;533;850 USD

The INHBB protein complexly controls pituitary function, regulating follicle-stimulating hormone and activin. Its critical role extends to a variety of physiological processes, including hormone secretion, cell development, insulin release, and bone growth. INHBB Protein, Human (HEK293, His) is the recombinant human-derived INHBB protein, expressed by HEK293 , with C-10*His labeled tag. The total length of INHBB Protein, Human (HEK293, His) is 379 a.a., with molecular weight of ~17.52 & 40.53 & 53.75 kDa, respectively.

Human

INHBB protein assumes a crucial role in the intricate orchestration of pituitary gland function, contributing to the dual regulatory dynamics of inhibiting and activating follitropin secretion alongside activins. The far-reaching impact of inhibins and activins, with INHBB as a pivotal component, extends across a spectrum of physiological processes, including hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development, and bone growth, contingent upon their distinctive subunit compositions. Notably, inhibins, exemplified by Inhibin A and Inhibin B, emerge as counterparts opposing the functions of activins. Structurally, INHBB exists in a dimeric configuration, intricately linked by one or more disulfide bonds, representing a homodimer of beta-B subunits. The nuanced diversity within activins, including Activin A, Activin B, and Activin AB, further underscores their unique subunit compositions and their interactions with regulatory proteins such as FST and FSTL3. This intricate interplay highlights the central role of INHBB in fine-tuning a comprehensive regulatory network governing diverse physiological functions.

Activin beta-B chain; INHBB; Inhibin beta B chain

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.