protein

B7-H2/ICOSLG Protein, Human (HEK293, Fc)

HY-P7324

10 μg;50 μg

110;210 USD

B7-H2/ICOSLG Protein, Human (HEK293, Fc)

proteins

HEK293

10 μg;50 μg

110;210 USD

384647022

B7-H2/ICOSLG Protein, Human (HEK293, Fc) is a polypeptide chain containing the C-termimal human IgG1 Fc fragment produced in HEK293 cells. ICOSLG is a number of the B7 family of co-stimulatory molecules.

Human

As a member of the B7 family, inducible co-stimulator ligand (ICOSLG) expressed on tumor cell has been reported to have an important role in tumor immunity. As the counter ligand of ICOS, a CD28-related molecule, ICOSLG is expressed on professional antigen-presenting cell (APCs; such as dendritic cells (DCs) and B cells) and on some tumor cells (such as glioma cells and gastric carcinoma cells). ICOSLG is the only B7 family member that preferentially co-stimulates type 2T helper cell (Th2) responses, and interestingly, this unique molecule has a critical role in antitumor immunity. ICOSLG expression on solid tumors (implanted-transfected tumors) aids in both NK mediated and CD8 + cytotoxic T cell (CTL) activation and killing. Several studies using ICOSLG-transfected solid tumor cell lines found that ICOSLG induced CD8 + cytotoxic lymphocyte-mediated tumor regression [1] .

rHuB7-H2/ICOSLG, Fc Chimera; B7 homolog 2; B7RP-1; CD275

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against PBS, 5% trehalose and mannitol.

Room temperature in continental US; may vary elsewhere.