protein

NA/Neuraminidase Protein, Influenza A H5N1 (H255Y, HEK293)

HY-P73239

60 U

250 USD

NA/Neuraminidase Protein, Influenza A H5N1 (H255Y, HEK293)

proteins

HEK293

60 U

250 USD

Neuraminidase (NA) is described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. Whereby, NA facilitates viral invasion of the upper airways, facilitates virus release during virus budding, prevents self-aggregation and ensures the efficient spread of the progeny virus from cell to cell, and also plays a role in the determination of host range restriction on replication and virulence. NA/Neuraminidase Protein, Influenza A H5N1 (H255Y, HEK293) is the recombinant Virus-derived NA/Neuraminidase protein, expressed by HEK293 , with tag free. and H255Y mutation. The total length of NA/Neuraminidase Protein, Influenza A H5N1 (H255Y, HEK293) is 449 a.a., with molecular weight of ~49.2 kDa.

Virus

Neuraminidase (NA) is described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. NA may facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. NA catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates, cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release and additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell or the infection would be limited to one round of replication. NA also plays a role in the determination of host range restriction on replication and virulence [1] [2] .

NA; Neuraminidase

Lyophilized from a 0.2 μm filtered solution of PBS, 0.6% Triton X-100, 7% Trehalose, 6% Mannitol, pH 7.4

Room temperature in continental US; may vary elsewhere.